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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions. Schoenberger, S.P., Toes, R.E., van der Voort, E.I., Offringa, R. A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. CD4 T cell help is required for primary CD8 T cell responses to vesicular antigen delivered to dendritic cells in vivo. Serre, K., Giraudo, L., Siret, C., Leserman, L. CD4 + T cells are required for secondary expansion and memory in CD8 + T lymphocytes. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Regulatory T cells inhibit stable contacts between CD4 + T cells and dendritic cells in vivo. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. In situ characterization of CD4 + T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes. T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Miller, M.J., Hejazi, A.S., Wei, S.H., Cahalan, M.D. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Dynamics of CD8 + T cell priming by dendritic cells in intact lymph nodes. Nonlinear magic: multiphoton microscopy in the biosciences.